Anti -TRIAD3A (Triad Domain-containing Protein 3, Triad3, E3 Ubiquitin-protein Ligase
RNF216, RING Finger Protein 216, RNF216, U7I1, Ubiquitin-conjugating Enzyme 7-interacting
Protein 1, Ubce7ip1, Zinc Finger Protein Inhibiting NF-kappa-B, ZIN)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| TRIADs are novel zinc finger proteins characterized by the presence of Cysteine rich TRIAD domain consisting of DRIL motif flanked by 2 RING fingers. TRIAD3, a 56kD protein, is a novel member of this family. It contains 4 RLD domains in the centre and a proline-rich domain at the C-terminus. Localized in the cytoplasm, it interacts with RIP and inhibits TNF and IL1-induced NF-kappaB activation pathways. Reports suggest TRIAD3 acts as an E3-ubiquitin-protein ligase and promotes ubiquitination and degradation of TLR4 and TLR9, thereby regulating TLR signaling. It also interacts with HIV type I Vif protein and interferes in the early events of HIV-1 replication. | | | Catalog # | T8319-05E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human brain, heart, kidney, liver, lung, ovary, pancreas, small intestine, skeletal muscle, spleen, or testes. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide. | | Purity | Purified by Protein G affinity Chromatography. | | Immunogen | Synthetic peptide corresponding to a portion of human TRIAD3 between aa350-400. | | Specificity | Recognizes human TRIAD3A. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=6.3.2.-, UbcM4-interacting protein 83, Uip83, |
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