Anti -Triadin (TDN, TRDN, dJ166D18.1, DKFZp779I2253, MGC88285, OTTHUMP00000040354, TRISK,
TRISK 51, TRISK51, TRISK-51)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
B IF |
|
| The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR?s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR?s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95kD) transmits electrochemical signals to the SR through direct interaction with both DHPR?s and RyR?s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae. | | | Catalog # | T8320-01 | | Applications | Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9F322 | | Host | Mouse | | Source | Rabbit | | Concentration | As reported | | Form | 0.05% Sodium Azide; PBS diluted Ascites | | Purity | Ascites | | Immunogen | Rabbit skeletal muscle triads. | | Specificity | This antibody does not detect triadin from cardiac tissues. Species Crossreactivity: Crossreacts with Mouse and Rabbit. Not yet tested in other species. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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