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You are here:Home » Antibodies » Abs to Transcription Factors, TRIM (Tripartite Motif) » Anti -TRIM5a (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)

Anti -TRIM5a (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite
Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88,
RNF88)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IH
TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Catalog #T8465-02G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9F325
HostMouse
SourceHuman
ConcentrationNot determined
FormAs reported
PurityAscites
ImmunogenNi-NTA purified truncated recombinant human trim5 alpha encompassing amino acids 135-350.
SpecificitySpecies Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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