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You are here:Home » Biochemicals » Biochem-Maleimide, MTS & Sulfhydryl » [2-(Trimethylammonium)ethyl] Methanethiosulfonate Bromide (MTSET Bromide)

[2-(Trimethylammonium)ethyl] Methanethiosulfonate Bromide (MTSET Bromide)

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Specifications

Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABAA receptor channel and of lactose permease.
Catalog #T8488
At pH 7.5 and room temperature, MTSEA hydrolyzes with a half-life of about 15 minutes, MTSET hydrolyzes with a half-life of 10 minutes, and MTSES hydrolyzes with a half-life of 20 minutes. Routinely, one can use 2.5mM MTSEA, 1mM MTSET, or 10mM MTSES, applied for 1 to 5 minutes. (MTSET is 2.5 times as reactive with small sulfhydryl compounds as is MTSEA, and 10 times as reactive as MTSES). (Stauffer and Karlin, 1994; Karlin, personal communication).
For application to Xenopus Oocytes, dissolve the compounds in 115mM NaCl, 2.5mM KCl, 1.8mM MgCl2, 10mM Hepes, pH 7.5 with NaOH. MTS reagents decompose in buffer very quickly.
•DMSO is a good solvent for the MTS reagents which are not water soluble (i.e. the non-charged MTS reagents).
Melting PointAs Reported
SolubilityAs Reported
AtmosphereInert gas
Method for Determining IdentityProton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis
TLC ConditionsAs Reported
Bromide ContentAs Reported
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Moisture Sensitive.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards 
All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number91774-25-3
Molecular FormulaC6H16BrNO2S2
Molecular Weight278.23
SourceSynthetic
Purity~90%
FormAs Reported
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMTSET


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