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Abs to Receptors, Tyrosine Kinase
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Anti -TrkA (Tyrosine Kinase Receptor A) (High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1 transforming tyrosine kinase protein, p140-TrkA, Trk-A, GENE NAME: NTRK1, TRK)
Anti -TrkA (Tyrosine Kinase Receptor A) (High affinity nerve growth factor receptor,
Neurotrophic tyrosine kinase receptor type 1, TRK1 transforming tyrosine kinase protein,
p140-TrkA, Trk-A, GENE NAME: NTRK1, TRK)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E IH |
|
| TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. | | | Catalog # | T8663-03C | | Applications | Suitable for use in ELISA and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | ELISA: 1:5000 | | Immunohistochemistry: 1:1000; Staining of rat dorsal root ganglia is restricted to the known distribution of TrkA in small, nociceptive neurons. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O. | | Purity | Serum | | Immunogen | Extracellular domain of glycosylated human TrkA protein produced in CHO cells. | | Specificity | Recognizes human, rat, and mouse TrkA. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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