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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -TrkA (Tyrosine Kinase Receptor A, Nerve Growth Factor Receptor, NGFR)

Anti -TrkA (Tyrosine Kinase Receptor A, Nerve Growth Factor Receptor, NGFR)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IH FC
TrkA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TrkA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease.
Catalog #T8663-07
Applications
Suitable for use in Flow Cytometry, Immunohistochemistry
and Immunoprecipitation. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Frozen sections
Immunoprecipitation: Detects a band at ~140kD
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D813
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 150mM sodium chloride, pH 7.4, 0.02% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSKNBE neuroblastoma cell line transfected with TrkA (TRK receptor).
SpecificityRecognizes an epitope present in the extracellular domain of human TrkA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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