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Abs to Receptors, Tyrosine Kinase
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Anti -TrkA (Tyrosine Kinase Receptor A, Nerve Growth Factor Receptor, NGFR)
Anti -TrkA (Tyrosine Kinase Receptor A, Nerve Growth Factor Receptor, NGFR)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
IP IH FC |
|
| TrkA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TrkA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease. | | | Catalog # | T8663-07 | | Applications | | | Suitable for use in Flow Cytometry, Immunohistochemistry | | and Immunoprecipitation. Other applications have not been tested. | | Recommended Dilutions | Immunohistochemistry: Frozen sections | | Immunoprecipitation: Detects a band at ~140kD | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D813 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 150mM sodium chloride, pH 7.4, 0.02% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | SKNBE neuroblastoma cell line transfected with TrkA (TRK receptor). | | Specificity | Recognizes an epitope present in the extracellular domain of human TrkA. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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