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Abs to Receptors, Tyrosine Kinase
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Anti -TrkB (Tyrosine Kinase Receptor B) (BDNF, NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, Ntrk2, Trkb)
Anti -TrkB (Tyrosine Kinase Receptor B) (BDNF, NT-3 growth factors receptor, Neurotrophic
tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, Ntrk2,
Trkb)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
IH |
|
| Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. | | | Catalog # | T8663-20K | | Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. | | Subunit | Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. | | Applications | Suitable for use in Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | Immunohistochemistry: 1:1000-1:3000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | As reported | | Form | Supplied as a lyophilized powder. Reconstiutute with 100ul sterile water. | | Purity | Serum | | Immunogen | Synthetic peptide (AFPRLEPNSIDPENC) as part of rat mature TrkB protein (aa 23-36) conjugated to KLH. | | Specificity | Recognizes human and rat TrkB. Does not crossreact with TrkA and TrkC. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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