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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -Tyrosine kinase receptor type B (BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, Trk-B, TrkB, NTRK2, TRKB)

Anti -Tyrosine kinase receptor type B (BDNF/NT-3 growth factors receptor, Neurotrophic
tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, Trk-B, TrkB, NTRK2,
TRKB)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Tyrosine kinase receptor type B (TrkB) is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5, but not nerve growth factor (NGF). It is involved in the development and/or maintenance of the nervous system. It exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. It is a tran-membrane protein. There are 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. The different forms are differentially expressed in various cell types.
Catalog #T8663-30
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9G458
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
PurityPurified by affinity chromatography.
ImmunogenRecombinant protein of human Tyrosine kinase receptor type B (isoform TrkB-T1) with a GST tag.
SpecificityRecognizes human Tyrosine kinase receptor type B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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