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Anti -Troponin Complex, Cardiac (TnC, TnI, TnT, TNNC1, TNNT2, TNNI3)
Anti -Troponin Complex, Cardiac (TnC, TnI, TnT, TNNC1, TNNT2, TNNI3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E |
|
| The three-unit troponin complex (Troponin I, T and C), bound to tropomyosin, is located on the actin filament of skeletal and cardiac muscle. Troponin T binds to tropomyosin to form the troponin-tropomyosin complex. Troponin C binds calcium ions to produce a conformational change in Troponin I. Troponin I binds to the actin in thin myofilaments to hold the troponin-tropomyosin complex in place. When calcium binds to troponin, a conformation change is forced in troponin and tropomyosin, moving both proteins away from the myosin binding sites on the actin filaments. Thus, myosin can bind to actin and muscle contraction occurs. | | | Catalog # | T8665-11B | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Hybridoma | Spleen cells from immunized BALB/c mice were fused with cells of the SP2/0 mouse myeloma cell line. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 10F561 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Human native troponin complex. | | Specificity | Recognizes human native troponin, a complex of three proteins integral to muscle contraction. It does not cross-react with any of the individual components Troponin I, T or C. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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