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You are here:Home » Antibodies » Abs to Cardiac Markers » Anti -Troponin I, Cardiac (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3)

Anti -Troponin I, Cardiac (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817,
TNNC1, Troponin I Type 3 Cardiac, TNNI3)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Purified E B IH
Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits, the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place, because of which myosin cannot bind to actin in relaxed muscle. When Calcium binds to the Troponin C it causes certain confomational changes which leads to dislocation of troponin I. The letter I is given due to its inhibitory character.
Catalog #T8665-18
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended DilutionELISA: Use as a capture.
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1906 IgY, Chicken Pab Rb x Ch
I1906-10 IgY, Chicken-HRP Rb x Ch
I1906-12 IgY, Chicken-FITC Rb x Ch
I1906-14 IgY, Chicken-AP Rb x Ch
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~5mg/ml
FormSupplied as a liquid in TBS, pH 7.4, 0.1% sodium azide.
PurityPurified
ImmunogenHuman Troponin I (Cardiac)
SpecificityRecognizes human Troponin I (Cardiac).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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