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You are here:Home » Antibodies » Antibodies-Tumor Suppressors » Anti -TSC2 (Tuberous Sclerosis Complex 2, Tuberous Sclerosis 2 Protein, FLJ43106, LAM, TSC4, Tuberin)

Anti -TSC2 (Tuberous Sclerosis Complex 2, Tuberous Sclerosis 2 Protein, FLJ43106, LAM,
TSC4, Tuberin)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder, which is characterized by seizures, mental retardation and hamartomatous in multiple organs. The genetic disorder is caused by the mutation in two genes - TSC1 and TSC2. The TSC2 gene is located on the chromosome 16p13.3, and it encodes the protein tuberin(1). Tuberin can interact with hamartin, encoded by TSC1 gene, to form a physical and functional complex(2). Tuberin, together with hamartin, are widely localized within epithelial cells, lymphocytes, endocrine glands and central nervous system (CNS) throughout the both normal body and TSC patients(1). Several independent investigations have demonstrated that tuberin is directly phosphorylated by Akt(2,3) and is further involved in stimulating cell growth, which provide an important link between tuberin and growth factor signaling. The loss of tuberin is associated with cell cycle deregulation and tumor suppression(4,5).
Catalog #T9100-30
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsELISA: 0.1-1ug/ul
Western Blot: 1-3ug/ml
Immunoprecipitation (Native): 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No3G293
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant human tuberin protein.
SpecificityRecognizes human tuberin encoded on tuberous sclerosis-2 (TSC2) gene with ~200kD. It does not crossreact with hamartin encoded on tuberous sclerosis-1 (TSC1) gene. Reactivity is con rmed with tuberin and hamartin overexpressed cell lysates.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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