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You are here:Home » Antibodies » Abs to Tubulin » Anti -Tubulin, beta 3 (Tubulin beta III, Tubulin beta 3 Chain, TUBB 3, TUBB3, Neuron Specific beta III Tubulin, beta-4, MC1R, Tubulin beta 4, TUBB 4, TUBB4)

Anti -Tubulin, beta 3 (Tubulin beta III, Tubulin beta 3 Chain, TUBB 3, TUBB3, Neuron
Specific beta III Tubulin, beta-4, MC1R, Tubulin beta 4, TUBB 4, TUBB4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IH
Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. In adult tissues, the distribution of beta III is almost exclusively neuron-specific.
Catalog #T9155-03
ApplicationsSuitable for use in Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: frozen and paraffin. paraffin sections require pretreatment by trypsin or pronase. Optimal dilutions to be determined by the researcher.
Recommended Secondary Reagents F(ab')2 rabbit anti-mouse IgG (HRP)
Recommended Negative Controls Mouse IgG1 Negative Control
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3H3091
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by DEAE chromatography.
ImmunogenSynthetic peptide corresponding to an epitope within the C-terminal region of human class III beta tubulin.
SpecificityRecognizes class III beta-tubulin which is reported to be restricted to neuronal tissue. Clone 3H3091 has been used to investigate tumors of neuronal origin including neuroblastoma and ganglioneuroma. Class III beta tubulin has not been detected in tumors of non neuronal origin. Species Crossreactivity: Syrian hamster, rat, mouse, baboon, bovine, porcine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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