Anti -Tubulin Polymerization Promoting Protein (TPPP, TPPP/p25, TPPP 1, TPPP1, 25kD
Brain-specific Protein, Brain-specific Protein p25 alpha, Glycogen Synthase Kinase 3
(GSK3) Inhibitor p24, p24, p25, p25alpha)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IH IC FC |
|
| Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1).TPPP can induce aggregation of alpha-synuclein, and can accumulate in | | | oligodendroglial cell bodies containing fibrillized alpha- synuclein multiple system atrophy (MSA), a neurodegenerative disease.TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal | | | human brains (2). | | | | | | Applications: | | | Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | | Catalog # | T9156-65 | | Recommended Dilution | Flow Cytometry: 1:50 | | Western Blot: 1:500-1:1000 | | Immunohistochemistry: 1:250-1:500 | | Immunocytochemistry: 1:100-1:250 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H523 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as liquid in 50mM Tris-Glycine (pH 7.4), 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues in human TPPP | | Specificity | Recognizes human TPPP. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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