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Tumor Necrosis Factor alpha, Recombinant, Human (TNFa, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2)
Tumor Necrosis Factor alpha, Recombinant, Human (TNFa, Cachectin, TNF-alpha, Tumor
Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2)
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| Tumor necrosis factor-a (TNF-a) is a pleiotropic pro-inflammatory cytokine produced mainly by activated macrophages and in smaller amounts by several other types of cell. TNF-a has been isolated and characterized from a large number of mammals and fish species. TNF-a is expressed in two different forms: a soluble. Mature 17kD form and a transmembrane 26kD form. TNF-a interacts with two distinct cell-surface receptors : Tumor necrosis factor receptor 1(TNFR1) and TNFR2. these mediate the cellular actions. The actions of TNF-a are diverse and profound involving inflammation, apoptosis, cell proliferation and the stimulation of various aspects within the immune system. TNF-a is increasingly recognized as a key regulator of lipid metabolism in adipose tissue and protein catabolism in muscle and in disease states such as cancer, Acquired Immune Deficiency Syndrome (AIDS) and obesity-related insulin resistance. | | | Catalog # | T9160-10K | | Source | Recombinant corresponding to aa77-23, from human TNF-a, expressed in E.coli. | | Molecular Weight | ~17.5kD | | Endotoxin Level | 0.05EU/ug | | Specific Activity | The ED50 as determined by the cytolysis of murine L929cells in the presense of actinomycin D is 0.03-0.06 ng/ml. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | ~17.5kD | | Source | E.coli | | Purity | ~98% (SDS-PAGE) | | Concentration | As reported | | Form | Supplied as a liquid in 20mM Tris, pH 8.0, 1mM EDTA, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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