Tumor Necrosis Factor Receptor 1, Recombinant, Human (Tumor Necrosis Factor Receptor Type
I, TNF-RI, TNFR-I, TNFR1, TNF-R1, CD120a, p55, p60, TNFAR, Tumor Necrosis Factor Receptor
Superfamily Member 1A, TNFRSF1A)
Pricing
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| TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II, which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury. TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 162aa and having a total molecular mass of 18.2kD. TNFR1 Human Recombinant is purified by proprietary chromatographic techniques | | | Catalog # | T9161-05K | | Source | Recombinant corresponding to human TNFR1 expressed in E. coli. | | AA Sequence | MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESSGSF TASENHLRHC LSCSKCRKEM GQVEKSSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN | | Molecular Weight | ~18.2kD | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~18.2kD | | Source | E. coli | | Purity | ~97% (RP-HPLC, SDS-PAGE) | | Concentration | Not determined | | Form | Supplied as a lyophilized powder from 10mM sodium phosphate buffer, pH 7.5. Reconstitute with sterile dH2O to 100ug/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | MGC19588, Tumor Necrosis Factor Binding Protein 1, TBP1 |
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Download Specifications for Tumor Necrosis Factor Receptor 1, Recombinant, Human (Tumor Necrosis Factor Receptor Type I, TNF-RI, TNFR-I, TNFR1, TNF-R1, CD120a, p55, p60, TNFAR, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNFRSF1A) |
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