Anti -Tumor Necrosis Factor Receptor 1, p55/p60 (TNFR 1, CD120a, MGC19588, p55, p55 R,
TNFR55, Tumor Necrosis Factor alpha Receptor, Tumor Necrosis Factor Binding Protein 1,
TBP1, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNFRSF1a)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH FC |
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| TNF-RI (~55-60kD) is present on most cell types and is considered to play a prominent role in cell stimulation by TNFalpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-R1 and TNF-R2, which have both distinct and overlapping downstream signaling cascades. Induction of | | | cytotoxicity and other functions are mediated largely via TNF-RI. TNF-R1 is equally well activated by both the 17kD soluble and 26kD membrane-bound form, whereas TNF-R2 is efficiently activated only by the membrane bound form of TNF-alpha. TNF-R1 signaling is initiated when trimeric TNF-alpha binds TNF-R1 receptors. Subsequent TNF-R1 trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor | | | of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-R1-deficient mice indicate that TNF-R1 mediates most of the proliferation, pro-inflammatory and apoptosis-activating pathways. | | | Catalog # | T9161-07 | | Applications | Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation, ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:50 | | Immunohistochemistry (Frozen): 1:50. | | Western Blot: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 6A657 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human Tumor Necrosis Factor Receptor 1, p55/p60 (TNFR1). | | Specificity | Recognizes the soluble and extracellular part of human TNFR1. Competes with TNF-alpha. Does not crossreact with TNFRII. Species Crossreactivity: Rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Tumor Necrosis Factor Receptor 1, p55/p60 (TNFR 1, CD120a, MGC19588, p55, p55 R, TNFR55, Tumor Necrosis Factor alpha Receptor, Tumor Necrosis Factor Binding Protein 1, TBP1, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNFRSF1a) |
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