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Anti -Tumor Necrosis Factor Receptor Associated Factor 3, CT (TRAF-3)
Anti -Tumor Necrosis Factor Receptor Associated Factor 3, CT (TRAF-3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E B IH |
|
| Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll- like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF- B (4). Besides CD40, TRAF3also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbR (5). | | | Catalog # | T9161-56C | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilution | Western Blot: 1:1000 Detects a band at 64kD. | | Immunohistochemistry (paraffin sections): 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | 3Y3cell lysate | | Storage and Stability | | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide cooresponding to aa 5-25, KKMDSPGALQTNPPLKLHTDR, of human TRAF3. (Genbank accession No. NP_663777). | | Specificity | Recognizes human TRAF3 and TRAF3b. Does not recognize other members of the TRAF family. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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