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You are here:Home » Antibodies » Abs to TRAF » Anti -Tumor Necrosis Factor Receptor Associated Factor 3, CT (TRAF-3)

Anti -Tumor Necrosis Factor Receptor Associated Factor 3, CT (TRAF-3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IH
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll- like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF- B (4). Besides CD40, TRAF3also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbR (5).
Catalog #T9161-56C
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:1000 Detects a band at 64kD.
Immunohistochemistry (paraffin sections): 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive Control3Y3cell lysate
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa 5-25, KKMDSPGALQTNPPLKLHTDR, of human TRAF3. (Genbank accession No. NP_663777).
SpecificityRecognizes human TRAF3 and TRAF3b. Does not recognize other members of the TRAF family.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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