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You are here:Home » Molecular Biology » MB-Growth Factors-TNF » Tumor Necrosis Factor Receptor 2, Recombinant, Human (TNFR2, CD120b)

Tumor Necrosis Factor Receptor 2, Recombinant, Human (TNFR2, CD120b)


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CD120b, otherwise known as sTNF receptor type II (sTNFR1I), is a member of the tumor necrosis factor receptor (TNFR) superfamily, produced by proteolytic cleavage of the membrane form by the metalloprotease TACE. CD120b plays a key role in regulating the inflammatory response, acting as a receptor for both tumor necrosis factor alpha (TNF-alpha) and TNF-beta, and is also involved in programmed cell death and anti-viral activity. sTNFR1I acts as an inhibitor of TNF-alpha induced responses, by acting as a decoy receptor.
Catalog #T9162-73B
SourceE. coli
ApplicationsSuitable for use in Functional Assays. Other applications not tested.
Biological ActivityDetermined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25ng/ml of recombinant human TNF-alpha is 0.125ug/ml.
Endotoxin 1EU/ug
Molecular Weight 18.9kD (174 amino acid residues)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight18.9kD
SourceE. coli
Purity98% (SDS PAGE and HPLC).
FormSupplied as a lyophilized powder. Reconstitute with 200ul sterile ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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