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TNFRSF17, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 17, B-cell Maturation Protein, BCM, BCMA, CD269)
TNFRSF17, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 17, B-cell
Maturation Protein, BCM, BCMA, CD269)
Pricing
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| TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. TNFRSF17 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 50aa and having a molecular mass of 5.3kD. The TNFRSF17 is purified by standard chromatographic techniques. | | | Catalog # | T9162-85 | | Source | Recombinant corresponding to human TNFRSF17 expressed in E. coli. | | AA Sequence | AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA | | Molecular Weight | ~5.3kD | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~5.3kD | | Source | E. coli | | Purity | ~98% (RP-HPLC, SDS-PAGE) | | Concentration | Not determined | | Form | Supplied as a lyophilized powder from 20mM sodium phosphate buffer, pH 7.4, 130mM sodium chloride. Reconstitute with sterile dH2O to 100ug/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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