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You are here:Home » Growth Factors, Cytokines » Growth Factors-Apoptosis » TWEAK, Recombinant, Human (TNF-related Weak Inducer of Apoptosis, APO3 Ligand, APO3/DR3 Ligand, APO3L, CD255, DR3LG, FN14, HCG1991317, MGC129581, MGC20669, Tumor Necrosis Factor Ligand Superfamily Member 12, TNFSF12, UNQ181/PRO207)

TWEAK, Recombinant, Human (TNF-related Weak Inducer of Apoptosis, APO3 Ligand, APO3/DR3
Ligand, APO3L, CD255, DR3LG, FN14, HCG1991317, MGC129581, MGC20669, Tumor Necrosis Factor
Ligand Superfamily Member 12, TNFSF12, UNQ181/PRO207)

Pricing

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Specifications

Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many members of the TNF family, was able to induce interleukin-8 synthesis in a number of cell lines. Recombinant Human TWEAK is a 17.0kD protein, comprising the TNF-like extracellular domain of TWEAK.
Catalog #T9185
Endotoxin 0.1ng/ug (1EU/ug)
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC (peripheral blood mononuclear cells) is less than 10ng/ml. TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN-y. The ED50 for this effect if between 30-45ng/ml.
AA SequenceMKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
ReconstitutionReconstitute in 10mM sodium phosphate pH 7.5 to a concentration of 1mg/ml.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of OriginUSA
SourceE.coli
Purity98% by SDS-PAGE and HPLC.
FormSupplied as a lyophilized powder from 10mM sodium phosphate, pH 7.5, 0.1M L-Arg.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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