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Twisted Gastrulation Protein, Recombinant, Human (TSG)
Twisted Gastrulation Protein, Recombinant, Human (TSG)
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| Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22kD protein containing the BMP/TGF binding portion of the full length TSG protein. | | | Catalog # | T9188 | | Biological Activity | Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is < 2.0 mg/ml of TSG. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile dH2O, carrier protein, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Country of Origin | USA | | Molecular Weight | 22kD | | Source | E. coli | | Purity | 98% by SDS-PAGE and HPLC analyses. | | Form | Supplied as a lyophilized powder in 10mM sodium acetate, pH6.0. Reconcentrate with dH2O, carrier protein to a concentration of 0.1-1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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