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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -TYK2 (Tyrosine Kinase 2, JTK1, Non-receptor Tyrosine Protein Kinase 2, Non-receptor Tyrosine Protein Kinase TYK2, Protein Tyrosine Kinase 2)

Anti -TYK2 (Tyrosine Kinase 2, JTK1, Non-receptor Tyrosine Protein Kinase 2, Non-receptor
Tyrosine Protein Kinase TYK2, Protein Tyrosine Kinase 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
TYK2 belongs to the Jak family of nonreceptor tyrosine kinases which includes four mammalian members, Jak1 to 3 and TYK2. Jaks play a pivotal role in signaling via a number of cytokines and growth hormones. Jaks associate with the intracellular domains of cytokine receptors and become phosphorylated upon ligand binding. Activated Jaks phosphorylate tyrosine residues of the respective receptor chains, which, in turn, leads to the recruitment and subsequent phosphorylation of STATs. Phosphorylated STAT proteins form homo- and/or heterodimers, translocate to the nucleus, and regulate cytokine-responsive genes. TYK2 initially identified by its essential role in type I IFN signaling, was subsequently shown to be involved in signaling via a number of other cytokines. Studies of human cell lines also revealed structural functions of Tyk2 for transport and stabilization of the IFNAR1. Human TYK2 gene is mapped to chromosomal region 19p13.2.
Catalog #T9220-01H
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).
SpecificityRecognizes human TYK2. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.7.10.2


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