Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » MB-14-3-3 » Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (14-3-3 epsilon, Mitochondrial Import Stimulation Factor L, Protein Kinase C Inhibitor Protein 1, YWHAE), Recombinant, Human

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, epsilon
Polypeptide (14-3-3 epsilon, Mitochondrial Import Stimulation Factor L, Protein Kinase C
Inhibitor Protein 1, YWHAE), Recombinant, Human

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms that have been identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Recombinant human 14-3-3 _ was expressed in E.coli and purified by using conventional chromatography techniques.
Catalog #T9247-87
SequenceMDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW
RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF
YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF
YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE
EQNKEALQDV EDENQ
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight29 kDa
SourceHuman, Recombinant, E. coli
Purity95% by SDS-PAGE. Purified by chromatography techniques.
Concentration1mg/ml
FormSupplied as a liquid in In 20mM Tris pH 7.5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesYWHAE, MDS, MDCR, KCIP-1, FLJ45465


External Links