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Abs to Ubiquitin Ligases
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Anti -Ubiquitin Conjugating Enzyme E2N (Ubiquitin-conjugating Enzyme E2 N, UBE2N, Bendless-like Ubiquitin-conjugating Enzyme, BLU, MGC8489, MGC131857, UBC13, UbcH-ben, Ubiquitin Carrier Protein N, Ubiquitin-protein Ligase N)
Anti -Ubiquitin Conjugating Enzyme E2N (Ubiquitin-conjugating Enzyme E2 N, UBE2N,
Bendless-like Ubiquitin-conjugating Enzyme, BLU, MGC8489, MGC131857, UBC13, UbcH-ben,
Ubiquitin Carrier Protein N, Ubiquitin-protein Ligase N)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Ubiquitin-conjugating enzyme 13 (Ubc13) was initially discovered in S. cerevisiae as a DNA-damage inducible protein involved in the error-free DNA postreplication repair pathway. It has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. Ubc13 is part of a dimeric ubiquitin-conjugating enzyme complex also containing UEV1A (ubiquitin-conjugating enzyme E2 variant 1) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation. | | | Catalog # | U1000-92H | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human small intestine or HepG2 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to human UBC13. | | Specificity | Recognizes human UBC13. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Ubiquitin-conjugating Enzyme E2N (UBC13 Homolog, Yeast), EC=6.3.2.19 |
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