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You are here:Home » Antibodies » Abs to Lectins » Anti -Ulex Europaeus Lectin 1 (UEA 1, UEA1, UEA I, UEA-I, Anti-H(O) Lectin 1, Anti-H(O) Lectin I, Ulex europaeus Agglutinin)

Anti -Ulex Europaeus Lectin 1 (UEA 1, UEA1, UEA I, UEA-I, Anti-H(O) Lectin 1, Anti-H(O)
Lectin I, Ulex europaeus Agglutinin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH IF
Lectins are highly specific carbohydrate binding proteins useful in carbohydrate and cell membrane studies, as well as cell agglutination and typing techniques.
Anti-Ulex Europaeus-I (UEA-I) Lectin is developed in rabbit using purified Ulex Europaeus-I lectin from gorse seeds as the immunogen. Anti-UEA-I Lectin is specific for UEA-I bound to vascular endothelium and squamous epithelium of human tonsil by indirect immunofluorescent staining. While erythrocytes may be stained,no other tonsilar elements are reactive with the antibody. Anti-UEA-I reacts with UEA-I bound to human endothelial cells of normal and neoplastic blood and lymphatic vessels. It also reacts with human epithelia such as in the colon, bronchus, epidermis, sweat gland ducts and hair follicles. Epithelia from other species may also react with the antibody. Anti-Ulex Europaeus-I Lectin may be used for studies of vascular structures in formalin-fixed, paraffin-embedded tissue or frozen tissue preparations. The antibody may be useful in the detection of vascular tumors, the investigation of vascular invasion by tumor cells, for determination of UEA-I binding to normal, embryonal, dysplastic and neoplastic epithelia, and the study of storage diseases such as fucosidosis Ulex Europaeus-I Lectin is a 46kD glycoprotein known to interact with alpha-L fucosyl residues in oligosaccharides present on the membranes of human blood group O erythrocytes, human endothelial cells and a variety of human and animal epithelial cells.
Catalog #U1500-50A
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive Control Human tissue
Cellular Localization Cytoplasmic (probable)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined
FormAs reported
PurityWhole antisera
ImmunogenUlex europaeus agglutinin isolated by affinity chromatography from seeds of Ulex europaeus (gorse seed).
SpecificityThe antibody may be used for studies of the vascular structures. It reacts specifically with UEA-I bound to human endothelial cells of normal and neoplastic blood and lymphatic vessels. Its uniform reaction with vessels enables differentation between vessels and artificial slits in the tissue.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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