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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -Uncoupling Protein 3 (UCP3)

Anti -Uncoupling Protein 3 (UCP3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The uncoupling proteins (UCPs) are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the phosphate and oxologutarate carriers and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP1 is abundantly expressed in brown adipose tissue of mammals. UCP1 allows proton re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP2 to be expressed by a variety of tissues. UCP3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney.
Catalog #U1622-11
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml. Detects an ~30kD protein representing UCP3 from rat heart homogenate.
Immunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa295-308, C-RALMKVQVLRESPF, of the mouse and rat UCP3 protein. Species Sequence Homology
SpecificityRecognizes mouse UCP3. Does not detect UCP3 from mouse liver or kidney. Species Crossreactivity: Human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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