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Anti -Uncoupling Protein 4 (Mitochondrial Uncoupling Protein 4, UCP 4, UCP4, FLJ33552, RP11-446F17.2, Solute Carrier Family 25 Member 27, SLC25A27, UNQ772/PRO1566)
Anti -Uncoupling Protein 4 (Mitochondrial Uncoupling Protein 4, UCP 4, UCP4, FLJ33552,
RP11-446F17.2, Solute Carrier Family 25 Member 27, SLC25A27, UNQ772/PRO1566)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| UCP4 is a 323aa mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats. UCP4 is a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. It reduces the mitochondrial membrane potential in mammalian cells and is involved in thermoregulatory heat production. UCP4 creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis resulting in dissipation of energy in the form of heat. UCP4 is usually found in adult and fetal brain, with low levels in spinal chord, corpus callosum and substantia nigra. | | | Catalog # | U1623-02 | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml | | Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Brain lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa250-300 of human UCP4. | | Specificity | Recognizes human UCP4. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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