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Anti -Urokinase Plasminogen Activator (uPA)
Anti -Urokinase Plasminogen Activator (uPA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Urokinase plasminogen activator (uPA) is a serine protease. It converts the abundant proenzyme plasminogen to active plasmin and plays a key role in cancer invasion and a variety of tissue remodelling processes such as wound healing, mammary gland involution and placental development(1-3). Elevated levels of uPA are associated with poor prognosis in many types of cancer (2-5). | | | Catalog # | U1820-14 | | Applications | Suitable for use in ELISA, Western blot and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | | | Western Blot: under reduced and non-reducing conditions | | Immunohistochemistry (frozen sections): 1:25 | | Optimal dilutions to be determined by the researcher. | | Culture Medium | | | RPMI 1640 with 10% fetal calf serum | | Hybridoma | NS1/AG4.1 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9B14 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH7.4, 15mM sodium azide. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Native human uPA | | Specificity | Recognizes the A-chain of human uPA. Binds single and two-chain uPA, uPA/PAI-1 complex and uPA/uPAR complex. A reaction isseen with the amino terminal fragment (ATF) but not with LMW uPA. It inhibits the enzymatic activity of uPA in the fibrin plate assay. No reaction with human tissue plasminogen activator (tPA) or with any other human plasma proteins. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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