Anti -Urotensin II (UII, U-II, Urotensin-2, UTS2, PRO1068, UNQ525/PRO1068)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E RIA |
|
| Urotensin II (U-II) is a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/ neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor. Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy. | | | Catalog # | U2800-02C | | Applications | Suitable for use in ELISA and Radioimmunoassay. Other applications not tested. | | Recommended Dilution | Radioimmunoassay: 0.24ug/ml will bind ~30% in a system using human 125I-Urotensin II as a tracer. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a lyophilized powder from PBS, pH 7.5. Reconstitute with 200ul sterile ddH2O. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to Glu-Thr-Pro-Asp-Cys-Phe-Trp- Lys-Tyr-Cys-Val (Disulfide Bridge: Cys5-Cys10) from human Urotensin II. | | Specificity | Recognizes human Urotensin II. Shows 69% crossreactivity with rat Urotensin II and 10% with mouse Urotensin II. Does not crossreact with Endothelin-1 (human, porcine, rat, mouse, canine or bovine), CN-22 (human, porcine, rat), rat Adrenomedullin (aa1-50), ANF (rat, rabbit, mouse), Bradykinin, human Angiotensin II, rat BNP-45, rat BNP-32 or rat PAMP-20. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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