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You are here:Home » Antibodies » Abs to Enzymes, ATPase » Anti -Valosin Containing Protein (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97 Subunit, ATPase p97, IBMPFD, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TER-ATPase, TERA)

Anti -Valosin Containing Protein (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97
Subunit, ATPase p97, IBMPFD, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase,
TER-ATPase, TERA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IH
Valsolin Containing Protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. p97/VCP (valosin containing protein) belongs to the AAA ATPase family, predicted molecular weight 97kD. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
Catalog #V1035-20C
Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:2000; Detects a band at ~97kD.
Immunohistochemistry (Frozen/paraffin): 1:500
Optimal dilutions to be determined by the researcher.
Positive ControlWhole cell lysate from cultured human B cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9F456
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide
PurityAscites
ImmunogenSynthetic peptide corresponding to aa792-806, CGGSVYTEDNDDDLYG, of human VCP with added N-terminal cysteine. Cellular Localization
SpecificityRecognizes human VCP. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMGC131997, MGC148092, MGC8560, Yeast Cdc48p Homolog


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