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You are here:Home » Biochemicals » Biochem-Antibiotics » Vancomycin Hydrochloride

Vancomycin Hydrochloride

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Specifications

Vancomycin is an aminoglycoside antibiotic, used in the treatment of infections caused by Gram-positive bacteria. vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). The main target of this antibiotic is the D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors, used by bacteria for constructing their cell walls. This prevents the reaction used to link peptidoglycan precursors together from taking place. Vancomycin binds with the substrate, not the enzyme, in contrast to the way penicillin inhibits peptidoglycan synthesis.
Catalog #V2049
The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Under normal circumstances, this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis in two ways. It prevents the synthesis of the long polymers of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) that form the backbone strands of the bacterial cell wall, and it prevents the backbone polymers that do manage to form from cross-linking with each other.
Potency (as Vancomycin) 900ug/mg
pH (50mg/ml, 25°C) 2.5-4.5
Purity Purified by chromatography to pass USP
Moisture ~5%
Appearance White to light orange with a brown cast powder
Solubility (200mg/4ml dH2O) Faint yellow to dark yellow, clear, complete
CAS Number1404-93-9
Molecular FormulaC66H75Cl2N9O24•HCl
Molecular Weight1485.7
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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