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You are here:Home » Antibodies » Abs to Cadherin » Anti -Vascular Endothelial Cadherin, phosphorylated (Tyr658) (VE-Cadherin, CD144)

Anti -Vascular Endothelial Cadherin, phosphorylated (Tyr658) (VE-Cadherin, CD144)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
VE-cadherin is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. It is linked to the actin cytoskeleton through a number of adaptor proteins including alpha, beta, and gamma catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. The interaction between cytosolic c-terminal Src kinase, SH2 domain and phosphorylated tyrosine 658 site of VE-Cadherin regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has been shown to lead to uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.
Catalog #V2109-52C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilution to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.3, 50% glycerol, containing 1 mg/ml BSA, and 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography
ImmunogenPhosphorylated VE-cadherin (Tyr658) synthetic peptide corresponding to human amino acid residues around tyrosine 658. The sequence is conserved in mouse, rat, porcine, bovine, canine, chicken and chimpanzee.
SpecificityThe antibody detects a 120kD protein of VE-cadherin. Epitope
Species Cross ReactivityHuman
Species Sequence HomologyThis sequence is 100% homologous in mouse, rat, chicken, chimpanzee, cow, dog and pig
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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