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Vascular Endothelial Growth Factor, Recombinant, Mouse (VEGF)
Vascular Endothelial Growth Factor, Recombinant, Mouse (VEGF)
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| VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant murine VEGF is a 39.0kD disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. | | | Catalog # | V2110-07 | | Biological Activity | Determined by the dose-dependent | | stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) | | using a concentration range of 1.0-5.0ng/ml. | | AA Sequence | MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR | | Storage and Stability | Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Country of Origin | USA | | Molecular Weight | 46.0kD | | Source | E. coli | | Purity | 98% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug) | | Form | Supplied as a lyophilized powder from 20mM Acetic Acid. Reconstitute with sterile ddH2O to a concentration of 0.1-1.0mg/ml which can | | further be diluted into other aqueous solutions. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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