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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -VEGF (Vascular Endothelial Growth Factor, Vascular Permeability Factor, VEGFA, VPF)

Anti -VEGF (Vascular Endothelial Growth Factor, Vascular Permeability Factor, VEGFA, VPF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
VEGF (vascular endothelial growth factor) is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF), involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability, inducing properties specific for the vascular endothelium. There are various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor
(VEGF/VPF) containing 206-, 189-, 165-, and 121-amino acid residues. These different species, with apparently similar biological activities (in vitro), arise from alternative splicing of the RNA transcript from a single gene. Of the four isoforms of VEGF, the smaller two, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two
(VEGF189 and VEGF206) remain cell associated.
Catalog #V2110-11
ApplicationsSutiable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin/Paraffin): 5-10ug/ml for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 minutes followed by cooling at RT for 20 min.
Positive ControlAngiosarcoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide. Also supplied without BSA and sodium azide. Use Cat # V2110-11X.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman recombinant VEGF165. Cellular Localization
SpecificityRecognizes human Vascular Endothelial Growth Factor (VEGF). Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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