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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -VEGF Receptor 1 (Flt1, VEGFR1) Soluble (Vascular Endothelial Growth Factor Receptor 1, sVEGFR-1, sFlt1)

Anti -VEGF Receptor 1 (Flt1, VEGFR1) Soluble (Vascular Endothelial Growth Factor Receptor
1, sVEGFR-1, sFlt1)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant E B IP IH IC
VEGFR-1 (vascular endothelial growth factor receptor 1) is a 180-kDa membrane receptor tyrosine kinase that is the receptor for vascular endothelial growth factor (VEGF), VEGFB and PGF. VEGF is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. VEGFR-1 has seven extracellular Ig-like domains; the second domain from the N-terminus is necessary and sufficient for high affinity VEGF binding. The biological effects of VEGF are mediated by VEGFR-1 and VEGFR-2, and two major tyrosine phosphorylation sites at Tyr 1213 and Tyr 1242 and two minor tyrosine phosphorylation sites at Tyr 1327 and Tyr 1333 exist in VEGFR-1.
Catalog #V2110-16E
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 1: 250
Immunocytochemistry: 1: 250
Immunoprecipitation: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No6k398
ConcentrationNot Determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
ImmunogenSynthetic peptide corresponding to residues in the N-terminus of human VEGFR1.
SpecificityRecognizes human VEGFR1 at ~180kD. Detects both VEGFR1 and its splice isoform sFlt1. Species Crossreactivity: mouse and rat (tested in Western Blot only)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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