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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -Vascular Endothelial Growth Factor Receptor 1 (VEGF Receptor 1, VEGFR 1, VEGFR1, VEGFR-1, EC 2.7.10.1, FLT, Fms-like Tyrosine Kinase 1, Flt 1, Flt1, Flt-1, Fms Related Tyrosine Kinase 1, Fms-related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Va

Anti -Vascular Endothelial Growth Factor Receptor 1 (VEGF Receptor 1, VEGFR 1, VEGFR1,
VEGFR-1, EC 2.7.10.1, FLT, Fms-like Tyrosine Kinase 1, Flt 1, Flt1, Flt-1, Fms Related
Tyrosine Kinase 1, Fms-related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Va

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
Catalog #V2110-16P
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:100-1:2000 detects a band at ~180-230kD. The theoretical MW of mouse VEGFR1 is ~150kD and human VEGFR1 is ~151kD. The difference in MW is likely due to glycosylation or other post translational modifications. With CSF-1R chimera transfected lysates a doublet is seen at ~150kD representing VEGFR-2. An unknown band is also seen at ~50kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to an internal region (between residues 800-900) of mouse VEGFR1. There is 87% identity between the immunogen and the VEGFR-2 protein. Cellular Localization: Type 1 membrane protein (isoform Flt1)
SpecificityRecognizes mouse VEGFR-1 with significant crossreactivity with the VEGFR-2 protein. Species Crossreactivity: human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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