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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Anti -Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, VEGFR 2, VEGFR2,
VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor,
KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B FC
Vascular endothelial growth factor receptor 2 (VEGFR-2, KDR, Flk-1) is a major receptor transducing the effects of VEGF into endothelial cells. Upon binding to specific ligands, VEGFR-2 undergoes autophosphorylation and becomes activated. Major autophosphorylation sites of VEGFR-2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059). Activation of the receptor leads to rapid recruitment of the adaptor proteins, including Shc, Grb-2, PI3 kinase, Nck and the protein tyrosine phosphatases SHP-1 and SHP-2. The signaling of VEGFR-2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and prouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo.
Catalog #V2110-18V2
ApplicationsSuitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 2-20ug/ml
ELISA: 1-15ug/ml
Western Blot: 3-20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No9F486
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, pH 7.4. No preservatives added. Reconstitute in sterile ddH2O.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human soluble extracellular Vascular Endothelial Growth Factor Receptor 2 native protein. Cellular Localization: Type I membrane protein
SpecificityRecognizes native human Vascular Endothelial Growth Factor Receptor 2 at ~110kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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