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You are here:Home » Antibodies » Antibodies-Peptides » Anti -Vasoactive Intestinal Peptide (VIP)

Anti -Vasoactive Intestinal Peptide (VIP)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IF
Vasoactive intestinal peptide (VIP) is a 28 amino acid peptide (human, chr 6q26-q27). It is expressed and secreted by neurons innervating primary and secondary immune organs such as lymph nodes with a MW of 20kD. VIP is a potent neurotrophic factor causes vasodilation, lowers arterial blood pressure, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP also modulates several T-lymphocyte activities including motility, cytokine production, proliferation and apoptosis, VIP exerts its biological activity by binding to two closely related class II G-protein-coupled receptors VPAC-1 and VPAC-2 beside this VIP has its own receptors VIPR1&2 (Vasoactive Intestinal Polypeptide Receptor 1&2) and VIPRRP (VIP receptor-gene repressor protein). VIP shows similarities to glucagon, secretin and gastric inhibitory peptide (GIP) as such it has been considered a member of the glucagon-secretin family. The VIP is 100% conserved in mouse, rat and human. VIP is considered to be a viable candidate for the development of treatments for rheumatoid arthritis, since treatment with VIP significantly reduced incidence of severity of arthritis, the therapeutic effect of VIP was associated with down regulation of both inflammatory and autoimmune components of the disease.
Catalog #V2115-01
ApplicationsSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 0.5-1ug/ml. Control peptide (Cat #V2115-01A) can be used to coat plates at 1ug/ml.
Western Blot: 1-10ug/ml (ECL)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa near the C-terminus of mouse Vasoactive Intestinal Peptide (VIP), conjugated to KLH.
SpecificityRecognizes mouse Vasoactive Intestinal Peptide (VIP). Species Sequence Homology: rat and human, 100%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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