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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Vav, phosphorylated (Tyr174) (Proto-oncogene VAV, Vav 1 Guanine Nucleotide Exchange Factor, VAV1)

Anti -Vav, phosphorylated (Tyr174) (Proto-oncogene VAV, Vav 1 Guanine Nucleotide Exchange
Factor, VAV1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Vav, which is predominantly expressed during adult life, is one of the genetic markers that correlate with the differentiation of the hematopoietic cells. Its functional importance has been extensively studied in T and B cells, in which it appears crucial for both development and functions. In non-lymphoid hematopoietic cells, Vav is mainly involved in the response of mature cells to a variety of stimuli that lead to spatial and temporal reorganization of the actin-based cytoskeleton during proliferation and phagocytosis. Vav acts as a potential target for gene therapy of myeloproliferative disorders. Human Vav gene maps to the chromosome 19 in the region 19p13.2.
Catalog #V2121-02E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Vav around the phosphorylation site of tyrosine 174 (E-I-YP-E-D).
SpecificityRecognizes human Vav when phosphorylated at Tyr174. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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