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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Vav1, phosphorylated (Tyr160) (GDP/GTP Exchange Factor)

Anti -Vav1, phosphorylated (Tyr160) (GDP/GTP Exchange Factor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Vav proteins belong to the guanidine nucleotide exchange factor family of proteins that couple receptors to Rho-GTPases. The Vav family has currently three members in mammalian cells (Vav1, Vav2, and Vav3). Vav1 contains multiple protein binding motifs, indicating a role for Vav1as an adaptor protein linking cell surface receptors to downstream signaling proteins. Vav1 is exclusively expressed in hematopoietic cells and plays a significant role in lymphocyte development and antigen receptor mediated activation of NFAT and NFkB, and in more delayed responses such as the production of cytokines, including IL-2, IL-3, IFN-y, and TNF-a. Vav1 is also reported to activate JNK, p21-activated kinase (PAK) and PLCy, implicating its critical role in calcium mobilization, and cytoskeletal rearrangement. Activation of several cell surface receptors including integrins, immune response receptors, or growth factor receptors leads to phosphorylation of Vav1 on tyrosine residues including tyrosine 160.
Catalog #V2121-07A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cells expressing wild-type human Integrin av and b3 proteins
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide derived from a region of human Vav1 that contains tyrosine 160. Species sequence homology: mouse and rat.
SpecificityRecognizes human Vav1. Species sequence homology: Other species (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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