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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -VAV3 (Vav 3 Guanine Nucleotide Exchange Factor, VAV-3, FLJ40431, Guanine Nucleotide Exchange Factor VAV3)

Anti -VAV3 (Vav 3 Guanine Nucleotide Exchange Factor, VAV-3, FLJ40431, Guanine Nucleotide
Exchange Factor VAV3)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization. Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac.
Catalog #V2121-15J
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:128,000
Western Blot: 0.3-1ug/ml, observed in human bone marrow lysates on ~80kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to CSGEQGTLKLPEK, from human VAV3, at internal region of the protein (NP_006104.4, NP_001073343.1).
SpecificityRecognizes human VAV3. Species sequence homology: Canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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