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You are here:Home » Biochemicals » Biochem-Mycotoxins » Verruculogen

Verruculogen

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Specifications

Verruculogen is a tremorgenic mycotoxin first isolated from Penicillium verruculosum in 1972 and the structure resolved as an indole alkaloid in 1974. Subsequent investigations have shown that verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is complex but is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels and is a cell cycle inhibitor blocking division at the M phase
Catalog #V2121-71
Source Aspergillus fumigatus MST-FP1133
Apperance White solid
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number12771-72-1
Molecular FormulaC27H33N3O7
Molecular Weight511.6
SourceAspergillus fumigatus MST-FP1133
Purity~95%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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