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You are here:Home » Molecular Biology » MB-Enzymes, Cytochrome » Warfarin, (R)(+) substrate for Cytochrome P450, 1A2, 3A4

Warfarin, (R)(+) substrate for Cytochrome P450, 1A2, 3A4

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Specifications

Warfarin (also known under the brand names Coumadin, Jantoven, Marevan, Lawarin, Waran, and Warfant) is ananticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. Warfarin was found to be effective and relatively safe for preventing thrombosis andembolism (abnormal formation and migration of blood clots) in many disorders. Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K, but rather antagonizes vitamin K recycling, depleting active vitamin K. Thus, the pharmacologic action may always be reversed by fresh vitamin K. Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant. The name warfarin stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization which funded the key research (WARF, for Wisconsin Alumni Research Foundation) and the ending -arin,indicating its link with coumarin.
Catalog #W0770
AppearanceOff-white powder
Label PrecautionsHighly toxic. Possible teratogen. Avoid skin contact and inhalation.
CAS Number5543-58-8
Molecular FormulaC19H16O4
Molecular Weight308.33
Purity96% (HPLC); Chiral Purity: 99%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names[3-(a-acetonylbenzyl)-4-hydroxycoumarin]


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