Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to WD Repeat Proteins » Anti -WD repeat domain 5 (WDR5, BIG3, BIG-3, BMP2-induced 3-kb gene protein, SWD3, WD repeat-containing protein 5)

Anti -WD repeat domain 5 (WDR5, BIG3, BIG-3, BMP2-induced 3-kb gene protein, SWD3, WD
repeat-containing protein 5)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
WDR5 (WD repeat-containing protein 5; also BMP2-induced 3 kb gene protein/BIG3) is a
nuclear, 36-40kD monomeric member of the WD family of repeat proteins. It is known to be
expressed in osteoblasts, osteocytes and chrondrocytes, among other cells, and appears to
serve as a structural organizer for the histone methyltransferase MLL1 complex. This complex
methylates histone H3, and within this complex, WDR5 binds to mono- or dimethylated histone
H3 and serves as an anchor for complex subunits RbBP5, Ash2L and MLL1. Human WDR5 is
334 amino acids in length. It contains seven WD domains (aa43-333) that likely participate in protein-protein interactions, plus a phosphorylation site at Ser267. There are three isoform variants for WDR5. Human and mouse WDR5 are absolutely identical in aa sequence.
Catalog #W1006-12
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, sterile 40-50% glycerol, 0.02% sodium azide, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with sterile ddH2O, sterile 40-50% glycerol, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant human WDR5, aa1-120.
SpecificityRecognizes endogenous human WDR5 at ~40kD. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links