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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin, DFNA14, DFNA38, DFNA6, DIDMOAD)

Anti -WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin,


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Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH IC IF
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
Catalog #W1023-70
ApplicationsSuitable for use in Immunofluorescence/Immunocytochemistry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:2000 detects a band at ~100kD and ~200kD representing the monomer and dimer forms of WFS1.
Immunoprecipitation: 2ul
Immunofluorescence (IC): 1:200
Immunohistochemistry (Frozen): 1:1000
Immunohistochemistry (Paraffin): 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationNot Determined
FormSupplied as a liquid.
ImmunogenA synthetic peptide corresponding to 110 amino acid from the N-terminal region of the human WFS1.
Cellular LocalizationEndoplasmic reticulum
SpecificityRecognizes human WFS1.Species crossreactivity: mouse, monkey and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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