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You are here:Home » Antibodies » Abs to Disease Markers » Anti -WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin, DFNA14, DFNA38, DFNA6, DIDMOAD)

Anti -WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin,
DFNA14, DFNA38, DFNA6, DIDMOAD)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH IF
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
Catalog #W1023-70
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:2000. Heat samples at 50°C for 30 minutes.
Immunoprecipitation: 2ul
Immunofluorescence: 1:200
Immunohistochemistry (Frozen): 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid.
PuritySerum
ImmunogenA synthetic peptide corresponding to 110 amino acid from the N-terminal region of the human WFS1.
Cellular LocalizationEndoplasmic reticulum
SpecificityRecognizes human WFS1 protein at ~100kD. Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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