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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -WISP2 (WNT1-inducible-signaling Pathway Protein 2, WISP-2, Connective Tissue Growth Factor-like Protein, CTGF-L, Connective Tissue Growth Factor-related Protein 58, CCN Family Member 5, CCN5, CT58, CTGFL, UNQ228/PRO261)

Anti -WISP2 (WNT1-inducible-signaling Pathway Protein 2, WISP-2, Connective Tissue Growth
Factor-like Protein, CTGF-L, Connective Tissue Growth Factor-related Protein 58, CCN
Family Member 5, CCN5, CT58, CTGFL, UNQ228/PRO261)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the aa level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Catalog #W1450-50D
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa102-117 of human WISP2 (KLH).
SpecificityRecognizes human WISP2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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