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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum E

Wnt5A is a nontransforming member of the Wnt family of secreted and cysteine-rich proteins that exert their cellular effects via autocrine or paracrine routes. It is a proto-oncogene that functions in modulating cell fate and cell behavior during vertebrate development and has an important role in the Wnt signaling pathway. It acts as a ligand for members of the frizzled family of seven transmembrane receptors. The protein also plays a role in preventing metastatic disease in invasive breast carcinomas. The protein has many conserved features like a hydrophobic signal sequence, Wnt1 family signature sequence (CKCHGvSGSC), and a number of other conserved aa residues. Human Wnt5A expression was detected only in neonatal heart and lung. The gene for human Wnt5A is localized on chromosome 3p21-p14.
Catalog #	W3028-01A
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilution	ELISA: 1:100-1:1000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	Not determined.
Form	Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Purity	Serum
Immunogen	Synthetic peptide corresponding to aa274-295 ([BLAST]AMRLNSRGKLVQVNSRFNSPT[BLAST]) of human Wnt5A.
Specificity	Recognizes human Wnt5A. Species Crossreactivity
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.