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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Wnt-1 (Wingless-type MMTV Integration Site Family Member 1, Wnt1, INT1, Proto-oncogene Int-1 Homolog, Proto-oncogene Wnt-1)

Anti -Wnt-1 (Wingless-type MMTV Integration Site Family Member 1, Wnt1, INT1,
Proto-oncogene Int-1 Homolog, Proto-oncogene Wnt-1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues.
Catalog #W3035-25D
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended Dilution
Western Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlRecombinant human Wnt-1
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenE. coli expressed recombinant human Wnt-1.
SpecificityRecognizes human Wnt-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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