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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Wnt2B (Wnt13, Protein Wnt-2b, Protein Wnt-13, Wnt2B Wingless-type MMTV Integration Site Family Member 2B)

Anti -Wnt2B (Wnt13, Protein Wnt-2b, Protein Wnt-13, Wnt2B Wingless-type MMTV Integration
Site Family Member 2B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Wnt2b is a signalling factor which acts as a ligand for members of the frizzled family of seven transmembrane receptors. It is thought to play a key role during mammalian early embryogenesis, and may also function as a stem cell factor for neural and retinal progenitor cells.
Catalog #W3035-40B
The Wnt2b gene encodes two alternative transcript variants; Wnt2B splicing variant 1 encodes secreted-type glycoprotein (Wnt2B isoform 1), while Wnt2B splicing variant 2 encodes a transmembrane-type glycoprotein (Wnt2B isoform 2).
Wnt2b has been implicated in gastric cancer, esophageal cancer and skin basal cell carcinoma.
ApplicationsSuitable for use in Immunohistochemistry (paraffin). Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 5-10ug/ml
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide - internal domain of human Wnt2b.
SpecificityRecognizes epitope within the internal region (IN) of human Wnt2b. Species sequence homology: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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