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You are here:Home » Antibodies » Abs to Ligands » Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1)

Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half.. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.
Catalog #X9501-06
ApplicationsImmunohistochemistry: 1:100-1:500. Frozen
Immunoprecipitation
Western Blotting: 1:1000-1:10,000. Detects a band of approximately 90kD
Recommended Secondary Reagents Sheep anti Rabbit IgG (Aff. Pur.) HRP
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by affinity chromatography
ImmunogenPeptide corresponding to a region of human XRCC1 encoded within exon 17
SpecificityRecognizes human XRCC1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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