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Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1)
Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
|
| X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half.. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair. | | | Catalog # | X9501-06 | | Applications | Immunohistochemistry: 1:100-1:500. Frozen | | Immunoprecipitation | | Western Blotting: 1:1000-1:10,000. Detects a band of approximately 90kD | | Recommended Secondary Reagents Sheep anti Rabbit IgG (Aff. Pur.) | HRP | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | 1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. | | Purity | Purified by affinity chromatography | | Immunogen | Peptide corresponding to a region of human XRCC1 encoded within exon 17 | | Specificity | Recognizes human XRCC1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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